We have to work at the level where we are and where we can have the most impact. For most people, that is local.
The good news is, the roots of many of our most pressing problems are substantially local as well -- and/or can be approached from a local organizational power base.
For instance, the major basis of economic injustice and instability is private appropriation of land rent. Secondarily, we have the myriad of taxes and restrictions on enterprise in our localities and States. The tax-shift issue, especially, is usually a State-level issue but achieving it will necessitate building coalitions at the local level in the major metro areas of the State.
Such areas are also likely to be the political bases of influential State and federal legislators as well.
What if we thought in terms of building coalitions starting at the ward office, town hall, or city hall; then the county and regional entities; then using those contacts to reach out to the State and federal legislators who would be interested in some or all of our reforms? This will differ from place to place, but in my area (Chicago), local and State legislators, and even our district's Congressman, are all connected to one particular suburban township office -- one in which I happen to work part-time. Also within 10 minutes' drive of home is the regional mayor's association which periodically holds public discussions on economic development. I attended the last one (apparently as one of few people there on my own time, not sent there on the clock by a local govt) and got to provide some input and make some contacts, including the State rep from the district adjoining mine.
I am not saying that every one will happen to have such opportunities so convenient to home, but if you're in a metro area you certainly can reach out to people who can reach out to other people.
Once you ascertain that, then begins the hard work – specific research, building contacts, actually crafting a proposal, etc. -- things we've not even begun yet in our area.
Frankly, I think the trade-agreement issue is one of the last we can expect to solve precisely because it is so insulated from the reach of normal citizens. However, it’s also not actually at the root of our problems.